NSRL for Chloroethane

The cancer potency of chloroethane was estimated from dose-response data of uterine tumors among female mice exposed by inhalation (NTP, 1989). The cancer potency estimate corresponds to the upper 95 percent confidence bound on the linear term of the multistage model fit to cancer dose-response data in experimental animals. The potency derivation takes into account body size differences between humans and experimental animals. The Proposition 65 “no significant risk level” (NSRL) is defined in regulation as the daily intake level posing a 10 lifetime risk of cancer. The cancer potency estimate and corresponding NSRL are given in Table 1.